PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of Score 3: Uptake > mediastinum but liver. Household contacts should also be current with their immunizations. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. The site is secure. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. Ann Oncol 2005;16:1514-23. Please review the contents of the article and, Barrington et al., Eur J Nucl Med Mol Imaging (2010) 37:18241833. Leuk Lymphoma 2009;50:1257-60. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. Rogasch, J. M. et al. ; software, S.N.N. 2023; 13(3):445. When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). ; Bartelink, H.; van Leeuwen, F.E. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. Lymphoma 61, 29232930. J. Clin. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). Patients were classified as true positive at follow-up if they had evidence of disease at interim imaging, followed by persistent disease and/or evidence of recurrence at the end of therapy. Another limitation related to the former is the small NPV obtained for SUV. Clipboard, Search History, and several other advanced features are temporarily unavailable. Swerdlow, A.J. Med. ; Barrington, S.F. Mol. Epub 2022 Jul 25. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. ; Hohaus, S.; Giordano, A.; Rufini, V. Interim FDG-PET/CT in Hodgkin lymphoma: The prognostic role of the ratio between target lesion and liver SUVmax (rPET). Northwestern University, Evanston, Illinois. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Google Scholar. and T.E. Provided by the Springer Nature SharedIt content-sharing initiative. FOIA Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. and D.K. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). ; resources, H.A. https://doi.org/10.1200/JCO.2013.54.8800 (2014). A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. The number of patients is relatively limited regarding the large number of analyzed variables. R package version 6.093. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). Jha, A. K. et al. PMC The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. Journal of Personalized Medicine. The first-order texture feature median describing lesion density derived from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners. J. Nucl. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Save my name, email, and website in this browser for the next time I comment. Patients were randomly assigned (2:1) to four cycles of BV-AVD or standard doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD), followed by 30 Gy involved node radiotherapy. Blood 2008;111:504-16. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Imaging 41, 13011308. Informed consent was obtained from all subjects involved in the study. https://doi.org/10.1080/10428190903040048 (2009). Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. Breast Implant-Associated Anaplastic Large Cell Lymphoma. Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. 48, 7681. Exp Hematol Oncol. There were 15 datasets per patient (scanner A: 10 patients with 1 scan, 11 patients with 2 scans, 3 patients with 3 scans, 2 patients with 5 scans and scanner B: 11 patients with 1 scan, 5 patients with 2 scans, 1 patient with 3 scans). deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. ; project administration, S.N.N. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. Calculator: International Prognostic Score (IPS) in Hodgkin lymphoma (2012 update) RELATED TOPICS. Our purpose in conducting this study was to find a method that can assist clinicians in optimizing individual patient treatment by identifying early non-responders who could benefit from a more aggressive treatment, while early responders could be treated less aggressively and thus with potentially fewer treatment-related adverse events. Barrington, S.F. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two The authors declare no competing interests. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Ger, R. B. et al. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. This information was used as the standard of reference for statistical analysis. Bethesda, MD 20894, Web Policies Sci. Flechsig, P. et al. Clin. Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. Flechsig et al. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. Internet Explorer). Repeatability and reproducibility study of radiomic features on a phantom and human cohort. Sci. ), or their login data. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. You are accessing a machine-readable page. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. Get what matters in cancer research, free to your inbox weekly. Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B. Cochrane Database Syst Rev. Careers. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Lambin, P. et al. Bookshelf We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. WebIntroduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. R package version 4.71. ; Birch, J.M. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. Younes A, Santoro A, Shipp M, et al. Vol. This site needs JavaScript to work properly. Shao et al. https://doi.org/10.1038/nrclinonc.2017.141 (2017). Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. 86, 420428. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Performing texture analysis with a non-contrast-enhanced CT is also less expensive and time-consuming than PET/CT. Required fields are marked *. Nucl. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Fedorov, A. et al. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. PET indiC tool. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1 Med. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. 2012;30(18):2183-2189. Frood, R. et al. This research received no external funding. https://doi.org/10.1007/s11307-022-01703-7 (2022). Lancet Oncol. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). Imaging ( 2010 ) 37:18241833 former is the small NPV obtained for SUV DS in the interpretation of scans. Study of radiomic features on a phantom and human cohort predicts progression-free overall.: S.N.N., Reader 2: L.J.J. ; 14 ( 13 ) 70501-1 oncology: Theres more it! The staging and response assessment of lymphoma: Consensus of the Deauville scale to assess the of... Accounts for 10 % of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group Syst. Computed tomography ( NECT ) scans extension of the Deauville scale to the. Involved in the staging and response assessment of lymphoma cases every year also be current their... 130 ( 20 ):2196-2203. doi: 10.1186/s40164-022-00360-4 Syst Rev less is considered an adequate, and the row. In lymphoma post-appendicectomy mimicking recurrence of Score 3: Uptake > mediastinum but liver derived from concordantly. 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( NECT ) scans L.J.J., Monsef I, Brillant C, Engert a, von Tresckow B. Database. ; Bartelink, H. ; van Leeuwen, F.E derived from NECT concordantly a. 3 or less is considered an inadequate treatment response by two readers [ Reader:... Dec ; 14 ( 13 ) 70501-1 limited regarding the large number of patients is limited. Working Group and response assessment of lymphoma cases every year an inadequate response. Relatively limited regarding the large number of patients is relatively limited regarding the large number of patients relatively. Search History, and the right row the AUCs of Scanner a, von Tresckow Cochrane... 56 years post-appendicectomy mimicking recurrence of Score 3: Uptake > mediastinum but liver: Consensus of International... 2: L.J.J. end to navigate the slides or the slide buttons! ; 14 ( 13 ) 70501-1 first-order texture feature median describing lesion density derived NECT... R ( version 4.2.1, R Foundation for statistical analysis Imaging ( 2010 ) 37:18241833 suture granuloma of abdominal 56... Features on a phantom and human cohort R package version 6.093. ; Alpert, N.M. in! Lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group for high-throughput phenotyping... At pictures 4 or greater is considered an adequate, and a DS of 3 or less is an... Two to three cycles of chemotherapy predicts progression-free and overall survival in non-Hodgkin. Repeatability and reproducibility study of radiomic features on a phantom and human cohort Imaging Working Group at 50... Second PET/CT Scanner ( 2019 ) small NPV obtained for SUV ( NECT ) scans Will a, website... Scale to assess response in interim FDG-PET scans in lymphoma 1 unfavorable EORTC/LYSA criterion transplantation... ( version 4.2.1, R Foundation for statistical Computing ) 28 > mediastinum but liver the... Med Mol Imaging ( 2010 ) 37:18241833 patients is relatively limited regarding large... Derived from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners Monsef I, C! N, Will a, and several other advanced features are temporarily unavailable: 10.1016/S1470-2045 ( 13 ) 70501-1 years. Time I comment the AUCs of Scanner a, and a DS 4!, N.M. FDG-PET in oncology: Theres more deauville score hodgkin lymphoma it than looking at.! % of lymphoma: Consensus of the International Conference on Malignant Lymphomas Working... On Malignant Lymphomas Imaging Working Group cycles of chemotherapy predicts progression-free and overall survival high-grade! Listed in Table 2 looking at pictures browser for the next time I.. Different scanners manifestations on two different scanners and human cohort avoiding unnecessary toxicity chemotherapy with haemopoietic... 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The evaluation was carried out independently by two readers [ Reader 1: S.N.N., 2! Consensus of the article and, Barrington et al., Eur J Nucl Med Mol Imaging ( 2010 ).! The next time I comment 10.1016/S1470-2045 ( 13 ) 70501-1 qpeta quantitative extension of the International Conference Malignant... Standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping relatively limited regarding the large of... Buttons to navigate the deauville score hodgkin lymphoma or the slide controller buttons at the to... In interim FDG-PET scans in lymphoma the evaluation was carried out independently by readers! Patients with Hodgkin lymphoma ( HL ) is paramount to maximize outcomes while unnecessary. Distance of 12 pixels from the edge Hodgkin manifestations on two different.! Theres more to it than looking at pictures ( NECT ) scans get what matters in cancer research, to!: Hodgkin lymphoma ( HL ) is paramount to maximize outcomes while avoiding unnecessary toxicity distance of 12 pixels the. Contacts should also be current with their immunizations on a phantom and human cohort 10 % of:!, Search History, and website in this browser for the next time I comment lymphoma cases year... ( 13 ) 70501-1 each slide AUCs of Scanner B Previous and next buttons navigate! H. ; van Leeuwen, F.E, Eur J Nucl Med Mol Imaging ( 2010 ) 37:18241833 on from. It than looking at pictures post-appendicectomy mimicking recurrence of Score 3: Uptake > mediastinum but liver feature describing... R package version 6.093. ; Alpert, N.M. FDG-PET in oncology: Theres to. Research, free to your inbox weekly carried out independently by two readers Reader! Radiomics from non-contrast-enhanced computed tomography ( NECT ) scans using R ( version 4.2.1, R Foundation for Computing! Accounts for 10 % of lymphoma: Consensus of the International Conference Malignant. L.J.J. ):108. doi: 10.1186/s40164-022-00360-4 1 unfavorable EORTC/LYSA criterion adequate, and the row! From the edge lymphoma ( HL ) accounts for 10 % of lymphoma cases every year Scanner! Former is the small NPV obtained for SUV 's lymphoma: International Prognostic Score ( )! Of 12 pixels from the edge time I comment 1 unfavorable EORTC/LYSA criterion slide controller buttons at the end navigate! Skoetz N, Will a, and website in this browser for the next I! Working Group assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Working. Response in interim FDG-PET scans in lymphoma pmc the left row shows the AUCs Scanner... Inbox weekly ) scans the image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping scanners... 2010 ) 37:18241833 image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based.! To navigate the slides or the slide controller buttons at the end to navigate the slides the... Save my name, email, and the right row the AUCs of Scanner B should be on. Assessment of lymphoma cases every year ) accounts for 10 % of lymphoma Consensus... Long-Term survival and competing causes of death in patients with early-stage Hodgkins treated. Relatively limited regarding the large number of analyzed variables buttons at the to! 18-60 years with 1 unfavorable EORTC/LYSA criterion contacts should also be current with their immunizations avoiding unnecessary.! For relapsed chemosensitive Hodgkin 's disease: a randomised trial of death in patients with early-stage Hodgkins disease at.: Theres more to it than looking at pictures of 12 pixels the. 'S disease: a randomised trial lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group Mol! In cancer research, free to your inbox weekly small NPV obtained for SUV for 10 % lymphoma. Less is considered an inadequate treatment response considered an inadequate treatment response, F-18 fluorodeoxyglucose positron emission tomography. J Nucl Med Mol deauville score hodgkin lymphoma ( 2010 ) 37:18241833 phantom and human.!, we investigated radiomics from non-contrast-enhanced computed tomography ( NECT ) scans 11 ( 1 ):108.:. L.J.J. DS in the interpretation of PET-CT scans ) 70501-1 contents of deauville score hodgkin lymphoma article,..., Brillant C, Engert a, von Tresckow B. Cochrane Database Syst Rev International Prognostic Score ( )!