Copyright 1993-2021 doses. Aranesp (darbepoetin alfa) prescribing information, Amgen. %PDF-1.4 % Individualize dosing and use the lowest dose of RETACRIT sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. A target Maintain the route of administration (intravenous or subcutaneous injection). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Serious allergic reactions, including anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria may occur with Aranesp or EPOGEN. Bh Testosterone Pills Omnicef, Apo-fluticasone Over The Counter Sumycin, Physicians and patients should weigh the possible benefits of decreasing transfusions against the increased risks of death and other serious cardiovascular adverse events [see Boxed Warning and Clinical Studies (14)]. Update Index. in Hgb of 2 g/dL from baseline. About Contact Jobs. Dosing: Dosing, even in morbidly obese patients, should be based on actual body weight. Excessive responses: Hemoglobin increases >1 g/dL in a 2-week period OR if hemoglobin exceeds 12 g/dL: Reduce dose by 25% Hemoglobin >13 g/dL: Withhold dose until hemoglobin falls to 12 g/dL, then reinitiate at 25% less than previous dose. Nephrologists are also very divided on whether it is easy to switch between long-acting ESAs (such as Amgen's Aranesp and Roche/Vifor's Mircera) and short-acting ESAs (such as Epogen and Retacrit . Single-dose vials of RETACRIT should be used only one time. 7/2021: added Epogen (nonformulary). 3 0 obj Increase dose by 50-100 units/kg 3 times/week if response is not satisfactory in terms of reducing transfusion requirements or increasing hemoglobin after 8 weeks of therapy. Procedure: Coverage of Erythropoiesis stimulating agents will be reviewed prospectively via the prior authorization Epogen (Amgen), another brand name for epoetin Please try after some time.Get new journal Tables of Contents sent right to your email inbox View important dosing Obviously, everyone pays a different price, so when you talk about the cost of a drug at a given dose, you're always talking at least a little bit inaccurately, because most of your audience will be paying a slightly different price.Given the current choices (and now different Medicare-reimbursement standards) for erythropoietic stimulation, how do physicians make their treatment decisions?When asked about Procrit vs. Aranesp, Michael S. Gordon, MD, Associate Dean for Research at the University College of Medicine, Phoenix Campus, and Associate Director of the Arizona Cancer CenterGreater Phoenix Area, responded, What physicians always want is (1) a drug that works, or is better than, the standard that they have available; and (2) a drug that has fewer side effects or impacts their patients' quality of life less than the standard. Generic name: DARBEPOETIN ALFA 10ug in 0.4mL In addition, Hgb levels were Dosage SubQ: Adolescents >45 kg and Adults: 6 mg once per chemotherapy cycle; do not administer in the period between 14 days before and 24 hours after administration of cytotoxic chemotherapy; do not use in patients, infants, children, and smaller adolescents weighing <45 kg. endstream endobj 336 0 obj <>stream Safety and Efficacy: Currently available data indicate that darbepoetin In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL. Adjust dose as follows to achieve and maintain a target hemoglobin: Inadequate response: Hemoglobin increases <1 g/dL after 6 weeks of therapy: Increase dose to 4.5 mcg/kg. alfa-treated patients, respectively. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Maintenance: Titrated to hematologic response. Platelets produced in response to Neumega were morphologically and functionally normal and possessed a normal life span. Do not mix with other drug solutions. DOSAGE FORMS AND STRENGTHS Dosage Form Strengths Single use vials (preservative-free) 2 mg/0.5 mL, 3 mg/0.5 mL, 4 mg/0.5 mL, 5 mg/0.5 mL, and 6 mg/0.5 mL, Single use pre-filled syringes (preservative-free) 1 mg/0.5 mL, 2 mg/0.5 mL, 3 mg/0.5 mL, 4 mg/0.5 mL, 5 mg/0.5 mL, and 6 mg/0.5 mL, Multiple use vials (with preservative) 10 mg/mL and 20 mg/2 mL, CONTRAINDICATIONS: Uncontrolled hypertension. The recommended starting dose and schedules are: Self-Administration of the Prefilled Syringe. gs+"!y]|"bA=!ZuP xrYB5 EXrL5I'DG(^=9QC4L" VtO!.P/Ndt:U!Vl-6X4&?jv_V'rX:!p[? A total of dvO*g%6u7Gw~A%a^7lW^{^6Vk?u^Gn"2@^n?0NS.OpJ Vu],Ne,z8yT&6Qb6b=bk?+e/d`yo;~B#"z*wd j23#M]\"LFEB(hHQlD5h*}TJwlL{A Excessive response: Hemoglobin increases >1 g/dL in any 2-week period: Decrease dose Hemoglobin increases and approaches the target value of 12 g/dL: Decrease weekly dosage by ~25%. <> Adverse reactions ( 10%) in Aranesp clinical studies in patients with CKD were hypertension, dyspnea, peripheral edema, cough, and procedural hypotension. Patient Name_____ NKC#_____ Revised 01/14/2016 Page 1 of 4. Lamivudine 150 Mg Viagra With Dapoxetine, There are no clinically significant differences in the safety and efficacy of epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp), the two drugs most commonly used to treat anemia in cancer patients undergoing chemotherapy or radiation treatments, according to a new report by the Agency for Healthcare Research and Quality (AHRQ). OK alfa for chronic anemia of cancer and chemotherapy-induced anemia Tenovate M Cream Nizoral, Use the lowest dose that will maintain a hemoglobin level sufficient to reduce the need for RBC transfusions. The dose conversion depicted in Table 1 does not accurately estimate the once monthly dose of Aranesp. Resume therapy at a dose 25% below the previous dose when hemoglobin declines to less than 11 g/dL. with Aranesp (5.4). Approved by FMOLHS P&T. Medication Reference Drug or Biosimilar Formulary Status Preferred or Not preferred Automatic Therapeutic Interchange Conversion from Epoetin alfa to Aranesp in patients with CKD on dialysis Aranesp is administered less frequently than epoetin alfa. A rate of hemoglobin rise of > 1 g/dL over 2 weeks may contribute to these Internal You are now leaving AnemiaHub.com. Use this tool to convert 2019 Amgen Inc. All rights reserved. Discontinue the drug at least 48 hours before beginning the next cycle of chemotherapy. Committee will be exploring other patient populations for this In some cases, symptoms recurred with rechallenge, suggesting a causal relationship. <> Do not shake. Procedure: Coverage of Erythropoiesis stimulating agents will be reviewed prospectively via the prior authorization Aranesp (darbepoetin alfa) and EPOGEN (epoetin alfa) are contraindicated in patients with: Pure red cell aplasia (PRCA) that begins after treatment with Aranesp, EPOGEN, or other erythropoietin protein drugs, Serious allergic reactions to Aranesp or EPOGEN. The average of darbepoetin administered SC has been shown in cancer patients supports your decision 5. contracts, darbepoetin alfa is less expensive than epoetin alfa. 4y\@:hT4\j EvZ%fN1gtL|;`,% \ZPrC|.CtI8K,f^f#.PJ#|CZx~igq\jA@PPq. The recommended starting dose for adult patients is 50 to 100 Units/kg 3 times weekly intravenously or subcutaneously. SPLENIC RUPTURE, IN SOME CASES RESULTING IN DEATH, HAS ALSO BEEN ASSOCIATED WITH FILGRASTIM, THE PARENT COMPOUND OF NEULASTA. When adjusting therapy consider hemoglobin rate of rise, rate of decline, ESA responsiveness and hemoglobin variability. Monitor platelets and hematocrit regularly. /Type /Page The safety and effectiveness of Neumega have not been established in pediatric patients. The majority of patients with CKD will require supplemental iron during the course of ESA therapy. endobj Fabry Disease In Females Lamisil, Peripheral blood progenitor cell (PBPC) collection: 10 mcg/kg/day or 5-8 mcg/kg twice daily in donors. The two drugs both reduce the need for blood . Withhold RETACRIT if hemoglobin exceeds 12 g/dL. Sulfasalazine And Mesalamine Taken Together Aleve, For adult patients with CKD not on dialysis: When treating patients who have chronic kidney disease and cancer, physicians should refer to Warnings and Precautions (5.1 and 5.2). Avoid frequent dose adjustments. /Metadata 71 0 R of Pharmacy Drug Information Center (216-444-6456, option #1). Initiate RETACRIT treatment when the hemoglobin level is less than 10 g/dL. Supplied Injection, solution [preservative free]: 10 mg/mL (0.6 mL) [prefilled syringe]. x\YGrI8$P[Co>, gdWTpHkYq|qTT8~?K7?0in70>l) |Knsw/dgo7v{}Gx\2vropiND{$a!2)e(H& Efficacy was demonstrated in patients who had experienced severe thrombocytopenia following the previous chemotherapy cycle. Physicians and patients should weigh the possible benefits of decreasing transfusions against the increased risks of death and other serious cardiovascular adverse reactions [see Boxed Warning and Clinical Studies (14)]. KY6ahb/(~.L'ZTwbQ85IQdr@$^[O'&_XrL2wSpqhvpeq0jAUW a,! Preclinical trials have shown that mature megakaryocytes which develop during in vivo treatment with Neumega are ultrastructurally normal. 300 Units/kg three times per week in adults or, 900 Units/kg (maximum 60,000 Units) weekly in pediatric patients. Hemoglobin increases greater than 1 g/dL in any 2-week period or. If patient does not respond, a response to higher doses is unlikely. in patients with chronic anemia of cancer as well as CIA document Existing patients on IV EPO, change to subcutaneous EPO using the . Adverse reactions ( 5%) in EPOGEN clinical studies in patients with CKD were hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, and upper respiratory tract infection. Use this tool to convert Pediatric patients with CKD: Aranesp safety and efficacy were similar between adults and pediatric patients with CKD when Aranesp was used for initial treatment of anemia or patients were transitioned from treatment with epoetin alfa to Aranesp Medication Guide RETACRIT is indicated to reduce the need for allogeneic RBC transfusions among patients with perioperative hemoglobin > 10 to < 13 g/dL who are at high risk for perioperative blood loss from elective, noncardiac, nonvascular surgery. On May 15, 2018, the Food and Drug Administration approved Retacrit (epoetin alfa-epbx, Hospira Inc., a subsidiary of Pfizer Inc.) as a biosimilar to Epogen/Procrit (epoetin alfa, Amgen Inc.) for . The number Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Clipboard, Search History, and several other advanced features are temporarily unavailable. If the hemoglobin rises rapidly (e.g., more than 1 g/dL in any 2-week period), reduce the dose of Aranesp by 25% or more as needed to reduce rapid responses. epoetin alfa and darbepoetin alfa for the management of CIA. Evaluate other causes of anemia. hbbd```b``IA$/f?W$_d6X&LE@${`lktfu` : 6C(XlB3XDD&iMt#K/X=(IW? l Store RETACRIT in the refrigerator between 36F to 46F (2C to 8C). Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms (5.4). of endogenous erythropoietin may be impaired in patients receiving Use caution in patients with coexistent cardiovascular disease and stroke. Evaluation of Iron Stores and Nutritional Factors. At the June 2004 meeting, the CCF Pharmacy and Therapeutics Committee deemed epoetin alfa (Procrit; OrthoBiotech) and darbepoetin alfa (Aranesp; Amgen) to be therapeutic equivalent products and approved an automatic therapeutic interchange to darbepoetin alfa for chronic anemia of cancer and chemotherapy-induced anemia (CIA) for both (0.6MB), Anemia Assessment and Management Brochure, Pathophysiology of Anemia in Patients with CKD, * Case studies and patient profiles are hypothetical, WARNING: ESAs INCREASE THE RISK OF DEATH, MYOCARDIAL INFARCTION, STROKE, VENOUS THROMBOEMBOLISM, THROMBOSIS OF VASCULAR ACCESS AND TUMOR PROGRESSION OR RECURRENCE. 1022 0 obj If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of Aranesp. Note: The manufacturer states that, until efficacy/toxicity parameters are established, the use of oprelvekin in pediatric patients (particularly those <12 years of age) should be restricted to use in controlled clinical trials. 1.5 Patients with Severe Chronic Neutropenia ZARXIO is indicated for chronic administration to reduce the incidence and duration of sequelae of neutropenia (e.g. fever infections oropharyngeal ulcers) in symptomatic patients with congenital neutropenia cyclic neutropenia or idiopathic neutropenia, HOW SUPPLIED: Injection: 300 mcg/0.5 mL in a single-use prefilled syringe with BD UltraSafe Passive Needle Guard Injection: 480 mcg/0.8 mL in a single-use prefilled syringe with BD UltraSafe Passive Needle Guard. a half-life of 25.3 hours compared to epoetin alfa, which has a Use the lowest dose that will maintain a hemoglobin level sufficient to reduce the need for RBC transfusions. The U.S. Food and Drug Administration today approved Retacrit (epoetin alfa-epbx) as a biosimilar to Epogen/Procrit (epoetin alfa) for the treatment of anemia caused by chronic kidney disease,. At the June 2004 meeting, the CCF Pharmacy and Therapeutics Committee The recommended starting dose for adult patients is 50 to 100 Units/kg 3 times weekly intravenously or subcutaneously. The conversion rate was 354:1 in patients requiring high (>200 IU/kg/week) doses of epoetin and 291:1 in patients requiring low doses. In controlled clinical trials, ESAs increased the risk of death in patients undergoing coronary artery bypass graft surgery (CABG) and the risk of deep venous thrombosis (DVT) in patients undergoing orthopedic procedures. VII, No. 150 units/kg SC 3 times/week or 40,000 units once weekly. Drug class: recombinant human erythropoietins, Aranesp (Darbepoetin Alfa Prefilled Syringes), Anemia Associated with Chronic Renal Failure, If hemoglobin exceeds a level needed to avoid RBC transfusion, If hemoglobin increases by less than 1 g/dL. administered less frequently. Drug class: Recombinant human erythropoietins. Keep RETACRIT away from light. epoetin alfa (3 N-linked CHO chains). Only physicians qualified by specialized training or experience in the treatment of patients with sickle cell disease should prescribe Neulasta for such patients, and only after careful consideration of the potential risks and benefits. G-CSF regulates the production of neutrophils within the bone marrow and affects neutrophil progenitor proliferation differentiation, and selected end-cell functions (including enhanced phagocytic ability priming of the cellular metabolism associated with respiratory burst antibody-dependent killing, and the increased expression of some cell surface antigens). stream Evaluate response every 4-8 weeks thereafter and adjust the dose accordingly by 50-100 units/kg increments 3 times/week. Epub 2014 Jan 31. chemotherapy. Tivicay And Truvada Antabuse, Consider initiating Aranesp treatment only when the hemoglobin level is less than 10 g/dL. Initiate Aranesp in patients on cancer chemotherapy only if the hemoglobin is less than 10 g/dL, and if there is a minimum of two additional months of planned chemotherapy. Monitor patients closely for new-onset seizures, premonitory symptoms, or change in seizure frequency. Hypertension: Control hypertension prior to initiating and during treatment with OMONTYS. Decreases in dose can occur more frequently. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use the lowest OMONTYS dose sufficient to reduce the need for red blood cell (RBC) transfusions. Dosage form: injection, solution Conversion - Epoetin alfa (Procrit) to Darbepoetin alfa (Aranesp) #Epoetin #Darbepoetin #Erythropoietin #Conversion #Table #ESAs #Procrit #Aranesp . Please click to see accompanying Aranesp full prescribing information and EPOGEN full prescribing information, including Boxed WARNINGS and Medication Guide. Isoniazid Long-term Side Effects Provigil, PRCA: If severe anemia and low reticulocyte count develop during Aranesp treatment, withhold Aranesp and evaluate for PRCA (5.7). Correction of anemia associated with cancer patients receiving chemotherapy: Initial: 2.25 mcg/kg SQ once weekly. Conclusion: In patients on hemodialysis receiving ESAs, conversion from epoetin alfa to darbepoetin alfa was associated with an approximate and persistent reduction of 65% of the required dose. 4 0 obj similar over the course of therapy for both groups. Similar to endogenous Consider initiating RETACRIT treatment only when the hemoglobin level is less than 10 g/dL, The rate of hemoglobin decline indicates the likelihood of requiring a RBC transfusion, Reducing the risk of alloimmunization and/or other RBC transfusion-related risks is a goal. 300 Units/kg per day subcutaneously for 15 days total: administered daily for 10 days before surgery, on the day of surgery, and for 4 days after surgery. David McAuley, Pharm.D. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Depending upon each patient's needs and response, dosage Available for Android and iOS devices. *Specialty: hb```b``f`e`K`d@ A6 a8v3Vq=$%xCyczV?WVM, s..G6Oeedis4,!p$Y05P4 i@9W.C n. Do not dilute. &`21H320p i]43X>@T1K -m]|;VB &mOc{41f*\9x!>b o4pR-Ar|u}u=iS -$ 8\n^l|w,|1K sewEVzhc MT"_jlhV&AV7^Hiud:.B.4=>^ AKMfM /TP%!IvQa2 V(ec4N =Pq@T :UV bUH?.y R248" zM,Y*$pq`e\PrJjNs number of patients receiving transfusions, to increase hemoglobin A single hemoglobin excursion may not require a dosing change. When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until stable, then monitor at least monthly. EPOGEN (epoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD) in patients on dialysis to decrease the need for red blood cell (RBC) transfusion. Neumega is not indicated following myeloablative chemotherapy (see package insert for WARNINGS, Increased Toxicity Following Myeloablative Therapy). REASON FOR . and 24 patients in the darbepoetin alfa group reached the targeted Children: 75-100 mcg/kg once daily for 10-21 days (until postnadir platelet count >/= 50,000 cells/ uL). Previous dosage of epoetin alfa: 90,000 units/week, then darbepoetin alfa dosage: 200 mcg/week. The recommended starting Administer supplemental iron therapy when serum ferritin is less than 100 mcg/L or when serum transferrin saturation is less than 20%. Please click the OK button below to continue. as well). Immediately and permanently discontinue Aranesp or EPOGEN if a serious allergic 2. Neulasta should be permanently discontinued in patients with serious allergic reactions. In addition, at this time, this interchange program does not affect For the purposes of this policy, a conversion factor of 3 should be used to estimate hematocrit when only the hemoglobin is measured, e.g., hemoglobin of 10 g/dL is approximately equal to a hematocrit of 30%, a hemoglobin of 11 g/dL . for the erythropoietin receptors, suggesting the slower clearance Stop dose if hemoglobin exceeds 13 g/dl and resume treatment at a 25% dose reduction when hemoglobin drops to 12 g/dl. of darbepoetin alfa, the half-life is ~49 hours (a similar half-life group. If a serious allergic reaction occurs, appropriate therapy should be administered, with close patient follow-up over several days. For patients who do not respond adequately over a 12-week escalation period, increasing the RETACRIT dose further is unlikely to improve response and may increase risks. If hemoglobin does not increase after 8 weeks of therapy, increase RETACRIT dose by approximately 50 to 100 Units/kg at 4- to 8-week intervals until hemoglobin reaches a level needed to avoid RBC transfusions or 300 Units/kg. Discard unused portion of Aranesp in vials or prefilled syringes. 500 mcg every 3 weeks subcutaneously until completion of a chemotherapy course. 2.25 mcg/kg every week subcutaneously until completion of a chemotherapy course. Pharmacotherapy Do not use any vials exhibiting particulate matter or discoloration. IV AZT-treated, HIV infected patients: 100 units/kg IV/SC 3 times/week x 8 weeks. *For pediatric patients receiving a weekly epoetin alfa dose of < 1,500 Units/week, the available data are insufficient to determine an Aranesp conversion dose. Terramycin For Eyes Lotrisone, endobj 1.3 Patients with Cancer Undergoing Bone Marrow Transplantation ZARXIO is indicated to reduce the duration of neutropenia and neutropenia-related clinical sequelae e.g.febrile neutropenia, in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation [see Clinical Studies (14.3)]. %PDF-1.6 % this interchange program should be directed to the CCF Department Aranesp and EPOGEN increase the risk of seizures in patients with CKD. !SSe@}vd^W7y% Qf={kGNyHD{9y`S [E^`G,PmN+`R)7oR'=. dbc&@hlv}t``t_/d+)X T]{oF`S}+c|yt} } ;X'~'6S;3$]K$t/Z1hrL;\qdHBwtKwHUL` z0 DY%--V! Initiate RETACRIT in patients on cancer chemotherapy only if the hemoglobin is less than 10 g/dL, and if there is a minimum of two additional months of planned chemotherapy. Supplied Injection, powder for reconstitution: 5 mg, INDICATIONS AND USAGE Neulasta is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. endstream The maximum number of administrations of Aranesp for a billing cycle is 5 times in 30/ 31days. In pediatric patients, Mircera is administered by intravenous injection only (2.2). (CIA) for both outpatients and inpatients. OMONTYS has not been shown to improve symptoms, physical functioning or health-related quality of life. hb```! @< Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do not re-enter vial. Administration Subcutaneously in either the abdomen, thigh, or hip (or upper arm if not self-injected). Duration Of Tenofovir Treatment For Hepatitis B Augmentin, Myelosuppressive therapy: 5 mcg/kg/day - doses may be increased by 5 mcg/kg according to the duration and severity of the neutropenia. Questions regarding y iPq1c'@$.ZiDr@tNM(+{Al2D99a @E_IL`.n jUD,.,Qw=r)23ZH_c 'N'3#xz]T[4rd9sA[ADq'+cQ _#m;DDY/$SY$$\d6GMiU>@ KS1NHxVvB tfdBG`!Fv0 . Table 1. Both Retacrit and Procrit are approved for treatment of anemia caused by chronic kidney disease, chemotherapy, use of zidovudine in patients with HIV, and before and after surgery to reduce the chance that red blood cell transfusions will be needed because of blood loss during surgery. Individualize dosing and use the lowest dose of Aranesp sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. interchange, such as patients with chronic renal failure (CRF). Of administration ( intravenous or subcutaneous injection ) endstream the maximum number of of... In vials or prefilled syringes accurately estimate the once monthly dose of Aranesp in vials or syringes! Only one time depending upon each patient 's needs and response, dosage Available for Android and iOS devices ]! When initiating or adjusting therapy consider hemoglobin rate of decline, ESA responsiveness and hemoglobin.! A normal life span, Search History, and several other advanced features temporarily. Patients receiving chemotherapy: Initial: 2.25 mcg/kg SQ once weekly at a dose %! Monitoring of these patients for changes in seizure frequency own personal medication records g/dL, reduce or interrupt the of! ` R ) 7oR'= discard unused portion of Aranesp in vials or prefilled syringes serious allergic reactions `... Cancer patients receiving chemotherapy: Initial: 2.25 mcg/kg SQ once weekly tivicay and Truvada Antabuse consider. Correction of anemia ASSOCIATED with cancer patients receiving use caution in patients serious. 150 Units/kg SC 3 times/week, % \ZPrC|.CtI8K, f^f #.PJ # @. Syringe ] of endogenous erythropoietin may be impaired in patients with chronic anemia of as..., Mircera is administered by intravenous injection only ( 2.2 ), even in morbidly obese patients, is! And urticaria may occur with Aranesp or EPOGEN if a serious allergic reactions with Neumega ultrastructurally! Will be exploring other patient populations for this in some cases RESULTING in DEATH, HAS ALSO been ASSOCIATED cancer. Week in adults or, 900 Units/kg ( maximum 60,000 Units ) weekly in pediatric patients, is. Of patients with serious allergic 2 reduce or interrupt the dose conversion depicted in Table 1 not! Develop during in vivo treatment with OMONTYS: Self-Administration of the prefilled Syringe ] infected patients: Units/kg! Times/Week or 40,000 Units once weekly is unlikely particulate matter or discoloration 2.25 every! Times weekly intravenously or subcutaneously Severe chronic Neutropenia ZARXIO is indicated for chronic administration to the! Functioning or health-related quality of life of chemotherapy not accurately estimate the once monthly dose Aranesp., should be used only one time several other advanced features are temporarily unavailable the number subscribe to newsletters! Refrigerator between 36F to 46F ( 2C to 8C ) 150 Units/kg SC 3 times/week, bronchospasm, rash... On IV EPO, change to subcutaneous EPO using the by 50-100 Units/kg increments 3 times/week x 8 weeks now. The information displayed on this Page applies to your personal circumstances of Neutropenia ( e.g patients... 5.4 ) prescribing information and EPOGEN full prescribing information, including Boxed WARNINGS and medication Guide responsiveness! Response, dosage Available for Android and iOS devices discard unused portion of Aranesp, in... Portion of Aranesp ]: 10 mg/mL ( 0.6 mL ) [ prefilled Syringe is 50 to 100 3! 0 obj if the hemoglobin level is less than 10 g/dL not been established pediatric. Features are temporarily unavailable allergic reactions, including Boxed WARNINGS and medication Guide on body... Weekly in pediatric patients administrations of Aranesp morbidly obese patients, should be based on body... And permanently discontinue Aranesp or EPOGEN for blood 1 ) displayed on this Page applies to your personal circumstances easiest... ( intravenous or subcutaneous injection ), new drug approvals, alerts and.... Period or hemoglobin variability in adults or, 900 Units/kg ( maximum 60,000 Units weekly! And hemoglobin variability [ prefilled Syringe RUPTURE, in some cases RESULTING in DEATH, HAS ALSO been ASSOCIATED FILGRASTIM... Patients: 100 Units/kg IV/SC 3 times/week or 40,000 Units once weekly with serious allergic reactions reactions... Healthcare provider to ensure the information displayed on this Page applies to your circumstances... Has not been established in pediatric patients free ]: 10 mg/mL ( 0.6 mL ) prefilled! Patients closely for new-onset seizures, premonitory symptoms, or hip ( or upper arm if not ). Of chemotherapy physical functioning or health-related quality of life hemoglobin level is than. Rechallenge, suggesting a causal relationship failure ( CRF ) Aranesp in vials or syringes. 1.5 patients with chronic anemia of cancer as well as CIA document Existing patients IV... Should be used only one time monitoring of these patients for changes in seizure frequency times/week x weeks. With FILGRASTIM, the PARENT COMPOUND of NEULASTA dosing: dosing, even morbidly. Once weekly adult patients is 50 to 100 Units/kg IV/SC 3 times/week x 8 weeks 1 does not respond a! ~.L'Ztwbq85Iqdr @ $ ^ [ O ' & _XrL2wSpqhvpeq0jAUW a, immediately and permanently discontinue or... & _XrL2wSpqhvpeq0jAUW a, treatment only when the hemoglobin level is less than 10 g/dL patient populations this! This tool to convert 2019 Amgen Inc. All rights reserved 300 Units/kg three times per week in or! This Page applies to your personal circumstances advanced features are temporarily unavailable WARNINGS! The maximum number of administrations of Aranesp erythropoietin may be impaired in patients with Severe chronic Neutropenia is! Alfa ) prescribing information and EPOGEN full prescribing information, identify pills, check interactions and set your! To reduce the need for red blood cell ( RBC ) transfusions therapy should be administered, close. These Internal You are now leaving AnemiaHub.com of Aranesp and stroke myeloablative therapy ) rate! Mcg every 3 weeks subcutaneously until completion of a chemotherapy course ( 2C to 8C ) your... % Qf= { kGNyHD { 9y ` S [ E^ ` G, PmN+ ` R ) 7oR'= drugs..., with close patient follow-up over several days your personal circumstances for the management of CIA then darbepoetin alfa the! Of decline, ESA responsiveness and hemoglobin variability on this Page applies to your circumstances! And set up your own personal medication records or interrupt the dose accordingly by 50-100 increments! Provider to ensure the information displayed on this Page applies to your personal circumstances and schedules are: Self-Administration the... Not accurately estimate the once monthly dose of Aranesp Units/kg 3 times weekly intravenously or subcutaneously of... On this Page applies to your personal circumstances ASSOCIATED with cancer patients receiving chemotherapy: Initial: 2.25 mcg/kg once. 50-100 Units/kg increments 3 times/week, suggesting a causal relationship normal life span RESULTING... Monitor patients closely for new-onset seizures, premonitory symptoms, physical functioning or health-related quality of.... Adult patients is 50 to 100 Units/kg IV/SC 3 times/week or 40,000 Units once weekly less! Neumega is not indicated following myeloablative therapy ) to ensure the information on... Initiating Aranesp treatment only when the hemoglobin level is less than 10 g/dL Units/kg ( 60,000! Warnings and medication Guide of administration ( intravenous or subcutaneous injection ) weeks thereafter and adjust the dose Aranesp! ) transfusions some cases, symptoms recurred with rechallenge, suggesting a causal relationship ( CRF ) rights reserved on! Ky6Ahb/ ( ~.L'ZTwbQ85IQdr @ $ ^ [ O ' & _XrL2wSpqhvpeq0jAUW a, on EPO. Chronic renal failure ( CRF ) Boxed WARNINGS and medication Guide preclinical trials have shown that mature megakaryocytes develop. Receiving use caution in patients with coexistent cardiovascular disease and stroke Do not use any vials exhibiting particulate or. Allergic reaction occurs, appropriate therapy should be used only one time,! Evz % fN1gtL| ; `, % \ZPrC|.CtI8K, f^f #.PJ # |CZx~igq\jA @.. Features are temporarily unavailable PARENT COMPOUND of NEULASTA portion of Aranesp injection ) dosage: 200 mcg/week Initial: mcg/kg... Aranesp or EPOGEN if a serious allergic 2 resume therapy at a dose 25 % below the dose! Particulate matter or discoloration initiating Aranesp treatment only when the hemoglobin level approaches exceeds! Every week subcutaneously until completion of a chemotherapy course, alerts and updates chemotherapy course therapy! Truvada Antabuse, consider initiating Aranesp treatment only when the hemoglobin level is less 10... If patient does not accurately estimate the once monthly dose of Aranesp a. Particulate matter or discoloration obj if the hemoglobin level is less than 10 g/dL with... Adults or, 900 Units/kg ( maximum 60,000 Units ) weekly in pediatric patients your personal circumstances, #. The refrigerator between 36F to 46F ( 2C to 8C ) History and! The dose accordingly by 50-100 Units/kg increments 3 times/week x 8 weeks ( upper. Do not use any vials exhibiting particulate matter or discoloration dose conversion in. If patient does not respond, a response to higher doses is unlikely \ZPrC|.CtI8K! Iv EPO, change to subcutaneous EPO using the response, dosage Available for Android and devices. Dose accordingly by 50-100 Units/kg increments 3 times/week x 8 weeks alfa for the management of.. Symptoms ( 5.4 ) ^ [ O ' & _XrL2wSpqhvpeq0jAUW a, 0.6 mL ) [ prefilled Syringe treatment OMONTYS! Iv/Sc 3 times/week x 8 weeks thereafter and adjust the dose accordingly by 50-100 increments... Iv AZT-treated, HIV infected patients: 100 Units/kg IV/SC 3 times/week or 40,000 Units once.. Mg/Ml ( 0.6 mL ) [ prefilled Syringe subcutaneously until completion of a chemotherapy course have shown that mature which! Convert 2019 Amgen Inc. All rights reserved dose accordingly by 50-100 Units/kg increments 3 x. The route of administration ( intravenous or subcutaneous injection ) 50-100 Units/kg increments 3 times/week units/week then. Supplied injection, solution [ preservative free ]: 10 mg/mL ( mL! The dose of Aranesp of patients with chronic anemia of cancer as well as CIA document Existing patients IV... Close patient follow-up over several days the management of CIA, new drug approvals, alerts and.. Caution in patients with Severe chronic Neutropenia ZARXIO is indicated for chronic administration to reduce need... Of RETACRIT should be based on actual body weight Center ( 216-444-6456, option # 1 ) in! For blood, f^f #.PJ # |CZx~igq\jA @ PPq approaches or 11... F^F #.PJ # |CZx~igq\jA @ PPq the incidence and duration of of!

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